Kidney disease, polycystic

The use of V2 antagonists is promising in the treatment of the hyponatremia that usually accompanies congestive heart failure and cirrhosis, two edematous conditions in which the use of diuretics is indicated. In addition, V2 antagonists may be beneficial in the treatment of polycystic kidney disease. 

PKD2, also called polycystin 2, is a TRP-related protein defective in human autosomal polycystic kidney disease, the most common life-threatening genetic disease. PKD2 appears to be a cation channel in the plasma membrane, although there is evidence that it is an intracellular Ca2+release channel. Mammalian homologs include polycystin-like (PCL). 

Polycystic kidney disease (Polycyst in-1 activates canonical Wnt signaling pathway) Injury-induced renal fibrosis Heart failure Ulcerative colitis Osteoporosis-Pseudoglioma Syndrome (genetic syndrome of defective bone formation) Ulcerative colitis Familial Alzheimer s disease (through interaction with Presenilin-1) Familial Alzheimer s disease (through interaction with Presenilin-1)... 

PCKD Polycystic kidney disease QA Quality assurance... 

Polycystic kidney disease A disorder in which clusters of cysts develop within the kidneys. 

Initiation factors initiate kidney damage and can be modified by drug therapy. Initiation factors include diabetes mellitus, hypertension, autoimmune disease, polycystic kidney disease, and drug toxicity. 

PKD Repeats in polycystic kidney disease 1 (PKD1) and other proteins E(M)AB 0(0) 0(0) 1B4R... 

Other examples of single-gene diseases with delayed age of onset include familial breast cancer, familial colon cancer, adult polycystic kidney disease, and hemochromatosis. 

Adult polycystic kidney disease (APKD) is one of the most common autosomal dominant diseases, affecting about 1/1,000 whites. The key feature of this disease is the progressive accumulation of renal cysts, which ultimately culminate in kidney failure. APKD is responsible for approximately 10% of end-stage renal disease in North America. Patients may also have hypertension, cerebral aneurysms, liver cysts, and cardiac valvular defects. 

A study of an extended family in Venezuela with Huntington s chorea demonstrated that family members with the disease show a distinct and characteristic pattern of restriction fragment lengths, leading to a new screening test. The same methods of investigation revealed patterns for cystic fibrosis, adult polycystic kidney disease, Due lien nc muscular dystrophy, and others. 

Roitbak, T., Ward, C. J., Harris, P. C., Bacallao, R., Ness, S. A., and Wandinger-Ness, A. (2004). A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells. Mol. Biol. Cell 15, 1334-1346. 

Keywords transient receptor potential, intracellular calcium, polycystic kidney disease, pain... 

Yoder, B. K., X. Hou and L. M. Guay-Woodford, 2002, The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia, J Am Soc Nephrol, 13, (10), pp. 2508-2516... 

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