Polycyclic aromatic hydrocarbons ovaries

Pal, K. 1984. The relationship between the levels of DNA-hydrocarbon adducts and the formation of sister-chromatid exchanges in Chinese hamster ovary cells treated with derivatives of polycyclic aromatic hydrocarbons. Mutat. Res. 129 365-372. 

Some toxicants are known to affect the female reproductive system and processes. Exposure to the alkylating agents cyclophosphamide and vincristine can lead to loss of female sexual function. Cyclophosphamide may attack and damage the oocytes, cells that lead to egg formation. Pharmaceutical busulfan damages ovaries. The 7,8-diol-9,10-epoxide of benzo(a)pyrene, as well as some other metabolites of polycyclic aromatic hydrocarbons, can be toxic to oocytes. 

Walton, D.G., A.B. Acton and H.F. Stich. Chromosome aberrations in cultured central mudminnow heart cells and Chinese hamster ovary cells exposed to polycyclic aromatic hydrocarbons and sediment extracts. Comp. Biochem. Physiol. 89C 395-402, 1988. 

AHH = aromatic hydrocarbon hydroxylase CHO = Chinese hamster ovary DNA = deoxyribonucleic acid FSHL = female sex hormone lutenizing NR = Not reported PAHs = polycyclic hydrocarbons SOS = DNA... 

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