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Polycarboxylic acid polymers activation

The toxicity of polycarboxylic acid polymers is more sensitive to polymer structure and molecular weight than antitumor activity. The acute toxicity is markedly decreased with decreasing molecular weight (Table VI and XI). Further,polyanion polymers have been shown to highly sensitize mice to bacterial endotoxin (39)> this activity is strikingly molecular weight dependent as shown in Tables VII and XI as well as dose dependent ( 3. The enhanced sensitivity to endotoxin by synthetic anionic polymers has been extensively studied, but the mechanism of action is still not understood (39)-... [Pg.210]

Macrophage Activation by Polycarboxyl Acid Polymer Immunopotentia-... [Pg.214]

R.M. Ottenbrite, J. Sunamoto, T. Sato, and M. Oka, Activation of alveolar macrophage with polycarboxylic acid polymers as immunomodulators, Polym. Prep., 26 (1), 212-213,1985. [Pg.299]

See other pages where Polycarboxylic acid polymers activation is mentioned: [Pg.50]    [Pg.85]    [Pg.106]    [Pg.135]    [Pg.549]    [Pg.438]    [Pg.140]    [Pg.103]    [Pg.508]    [Pg.272]    [Pg.283]    [Pg.400]   
See also in sourсe #XX -- [ Pg.214 , Pg.215 , Pg.216 ]



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Active polymers

Polycarboxylate

Polycarboxylic acid polymers

Polymer acid

Polymer activities

Polymers activator

Polymers, activation

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