Polyarylethyl ketone

Grant et al. (2002) designed a parallel system employing two HTLC columns (Cyclone, 50 x 1 mm, Cohesive Technologies) connected to one analytical column (Zorbax SB-C18, 50 x 2 mm, Hewlett Packard) on a 2300 HTLC. A polyarylethyl ketone (PAEK) six-port Valeo (Valeo Instruments, Texas) was used to increase switching speed and reduce carry-over. Peak focusing was used when the analyte was flushed from the TFC column into the analytical column by aqueous dilution. Compared to the dual column method, the overall time reduction was 1.5 to 4 min per sample with comparable data quality at the linear range of 0.1 to 100 ng/mL. 

As a final note in this discussion of on-line methods, it is widely known that on-line methods are more prone to system carryover. The primary reason is that the valves used for CS present additional surfaces for contact with the analyte. In a paper recently published by Grant and co-workers, the issue of analyte carryover in TFC was addressed [79]. These authors incorporated a series of multiple-wash steps along with a switching valve made of polyarylethyl ketone (PAEK) to reduce carryover present in a generic method that provided a throughput of 1.5 min/sample. 

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See also in sourсe #XX -- [ ]

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