Ring-opening polymerization polyanhydrides

Polyanhydrides Synthetic Melt condensation, ring-opening polymerization Most polyanhydrides soluble in organic solvents, insoluble in water... 

The most widely used method to synthesize polyanhydrides is melt condensation polymerization, which results in high molecular weight polymers. Other methods include Schotten-Baumann condensation, dehydrative coupling, and ring opening polymerization. 

Polyanhydrides have been synthesized by the following methods a) bulk melt condensation of activated diadds, b) ring opening polymerization, c) reaction between dibasic acid and diacid chlorides, and d) interfacial polymerization. A detailed study of these polymerization methods and various polymerization conditions for a range of diadds were previously described [25-27],... 

Synthesis of polyanhydrides is carried out through generalized methods such as melt polycondensation, solution polymerization, use of coupling agents, and ring-opening polymerization. 

Polyanhydrides have been synthesized by various techniques such as melt polycondensation, ring-opening polymerization, interfacial polycondensation, dehydrochlorination, and dehydrative coupling (13,14). The most widely used technique for polyanhydride synthesis is melt polycondensation, which occurs in two steps. In the first step, dicarboxylic acid monomers react with excess acetic anhydride to form acetyl-terminated anhydride prepolymers (1) with a degree of polymerization (DP) ranging from 1 to 20 (eq. 1). 

Polyanhydrides have been synthesized by melt condensation of activated diacids (Domb et al, 1987), ring opening pol) merization, dehydrochlorination, and dehy-drative coupling agents (Leong et al, 1987 Domb et al, 1988). Solution polymerization yielded in general low molecular weight pol miers. The most widely used method is the melt condensation of dicarboxylic acids treated with acetic anhydride ... 

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