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Polyanhydride-based drug delivery systems

Polyanhydrides degrade primarily by surface erosion and possess excellent in vivo compatibility. In 1996 the FDA approved a polyanhydride-based drug delivery system to the brain of chemotherapeutic agent BCNU, which is currently being manufactured by Guilford Pharmaceutical, Inc. [Pg.1643]

This chapter explores the development of biodegradable polyanhydride polymers as a local chemotherapeutic delivery system in brain tumor patients. In so doing, the authors detail the unique pharmacokinetic considerations inherent in CNS drug delivery, and the resultant advantages of local administration. Subsequent sections chronicle the development of biocompatible technologies, preclinical and clinical experience with polymer-based tumor treatments, and potential future advancements in local antineoplastic drug delivery. [Pg.325]

M.J. Kipper, E. Shen, A. Determan, and B. Narasimhan, Design of an injectable system based on bioerodible polyanhydride microspheres for sustained drug delivery. Biomaterials, 23, 4405-4412, 2002. [Pg.539]

See other pages where Polyanhydride-based drug delivery systems is mentioned: [Pg.2253]    [Pg.2253]    [Pg.447]    [Pg.90]    [Pg.89]    [Pg.284]    [Pg.12]    [Pg.370]    [Pg.263]    [Pg.334]    [Pg.83]    [Pg.222]    [Pg.182]    [Pg.180]    [Pg.144]    [Pg.105]    [Pg.182]    [Pg.278]    [Pg.856]    [Pg.61]    [Pg.383]    [Pg.2248]    [Pg.138]    [Pg.1012]    [Pg.1366]    [Pg.180]    [Pg.61]    [Pg.5948]    [Pg.36]    [Pg.38]    [Pg.34]    [Pg.38]    [Pg.165]    [Pg.666]   
See also in sourсe #XX -- [ Pg.2253 , Pg.2254 ]



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Polyanhydride

Polyanhydrides

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