Polyadenylic acid polyA

Eukaryotic mRNAs often have long 3 untranslated sequences— sequences that follow the stop codon for the protein they encode. These mRNAs generally conclude with a sequence of up to 200 adenosines, the polyadenylic acid (polyA) sequence at the 3 end. This sequence isn t coded by the DNA template for the gene it is added post-transcriptionally. Not all mRNAs are polyadenylated. For example, histone mRNAs lack polyA tails. Polyadenylation seems to play a role in regulating the stability of mRNAs. An early event in the breakdown of some mRNAs is the removal of their polyA tails. 

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