Polyacrylamide-silastic consumption

Table II shows the effect on platelet consumption of increasing lengths of the polyacrylamide-Silastic tubing. The acrylamide surface is much more destructive to platelets than is the Silastic surface. Table II also shows that platelet consumption increases linearly with shunt area for both the polyacrylamide-Silastic shunts.

Figure 11. Platelet consumption vs. graft level of polyacrylamide-Silastic shunts (9). (Numbers in parentheses refer to the number of shunts tested for each value reported.)...

Figure 12. Rates of production of thromboemboli volume ( 3Is) and equivalent platelet consumption by embolization (platelets/day) vs. surface area for two biomaterials Silastic (bottom) and polyacrylamide-Silastic (top). The equivalent steady-state platelet consumption is (3.0 0.2) x 108 (platelets day-cm2) for polyacrylamide-Silastic and (0.8 0.1) X 108 (platelets day-cm2) for Silastic.

A series of shunts with radiation and ceric ion-initiated grafts of polyacrylamide on the luminal Silastic surface, and having water contents varying between 51-83% were also studied. Table III shows these data. The platelet consumption increases linearly with the gel water, such that the ratio of platelet consumption to graft water content remains relatively constant. 

Exposed Area (cm2) Mean Platelet Survival Time (days) Cannula Platelet Consumption (platelets/day x 10 10) Polyacrylamide-grafted Silastic Cannula Platelet Consumption/ Unit Area (platelets/cm2 day x 10 H)... 

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