Poly succinylated

Experimentally it was found that the Gibbs activation energy for diacetyl piperazine (I) and poly(succinyl piperazine) [II, R = (CH2)2], poly(adipyl piperazine) [II, R = (CH2)4], and poly(sebacyl piperazine) [II, R = (CH2)g] are practically the same (A = 7.6 X 10" J/mol). The reason for this is not clear. The activation energy can, for example, be stored in the polymer molecule and used for the rotation about another bond. Alternatively, the tension set up by rotation can be compensated by distortion of rotational and valence angles. 

Fig. 1. The metabolic cycle for the synthesis and degradation of poly(3HB). (1) 3-ketothiolase (2) NADPH-dependent acetoacetyl-CoA reductase (3) poly(3HB) synthase (4) NADH-dependent acetoacetyl-CoA reductase (5), (6) enolases (7) depolymerase (8) d-(-)-3-hydroxybutyrate dehydrogenase (9) acetoacetyl-CoA synthetase (10) succinyl-CoA transferase (11) citrate synthase (12) see Sect. 3...

Figure 4.10. Dose-relationships for histamine release from rat mast cells induced by a variety of peptides [99], No calcium was added to the extracellular medium. Each point is the mean of two or more determinations A, poly(L-lysine) (molecular weight 30.000-70,000) , succinylated poly(L-lysine) (molecular weight 30,000-70f)00) V, [n-Phe7 )SP , fD-Prcr2, D-Phe7, D-Trpv]SP, u , SP/ A, eledoisin-related peptide , eledoisin O, N-terminal tetrapeptide of substance P.

SchemelO Chemical structure ofthe polypeptide obtained after introducing spiropyran units into the side chains of succinylated poly(L-lysine) (XVII). 70 ...

The complex surface chemistry of the metal oxides (section 4.2.1.2) is incompatible with their use in a number of chromatographic techniques. Polymer coated metal oxides are seen as an important approach to extending their scope. Alumina and zirconia particles coated with poly(butadiene), poly(styrene), poly(ethylene oxide), a copolymer of chloromethylstyrene and diethoxymethylvinylsilane and succinylated poly(ethyleneimine), for example, have been prepared for use in reversed-phase, size-exclusion and ion-exchange chromatography [44,46,54,120,134-137]. The methods of preparation are similar to those used for porous silica. 

Figure 17 Chemical structures of (a) poly(2-ethylacrylic acid) (PEAA), (b) hydrophobically-modified succinylated poly(glycidol), and (c) poly(NIPPAm-co-MAA-co-ODA). (Adapted from Ref. 101.)...

Poly(uridine) has been immobilized on agarose via a glycogen hydrazido-succinyl spacer arm and used for the affinity chromatographic purification of polyadenylated mRNA. ... 

Anhydro-alditols - The preparations of polyesters based on l,4 3,6-di-anhydro-D-glucitol and -o-mannitol with succinyl-, glutaryl- and adipoyl-dichlor-ides have been reported. Also reported have been the syntheses of poly(1 6)-2,5-anhydro-D-glucitol and its 3,4-di-0-alkylated derivatives by Lewis acid induced polymerization of 3,4-di-0-alkyl-l,2 5,6-dianhydro-D-mannitol base induced polymerization of l,2 5,6-dianhydro-3,4-di-0-methyl- or 3,4-di-O-iso-propylidene-D-mannitol base induced polymerization of l,2 5,6-dianhydro-3,4-di-O-pentyl- or di-O-decyl-o-mannitol and base induced polymerization of l,2 5,6-dianhydro-3,4-di-0-methyl-L-iditol. The solubilities of these 3,4-di-O-alkylated and deprotected polymers in aqueous and organic media were studied. Further, it has been reported that 2,5-anhydro-3,4-di-0-methyl-D-glucitol linked 1,6 to silica gel was useful for the optical resolution of amines and amino acid salts. ... 

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