Poly 2-methacryloyloxyethyl

Sugiyama K, Fukuchi M, Kishida A, Akashi M, and Kadoma Y. Preparation and characterization of poly (2-methacryloyloxyethyl phosphorylchohne-co-methyl methacrylate) graft copolyetherurethanes. 

Many kinds of nonbiodegradable vinyl-type hydrophilic polymers were also used in combination with aliphatic polyesters to prepare amphiphilic block copolymers. Two typical examples of the vinyl-polymers used are poly(/V-isopropylacrylamide) (PNIPAAm) [149-152] and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) [153]. PNIPAAm is well known as a temperature-responsive polymer and has been used in biomedicine to provide smart materials. Temperature-responsive nanoparticles or polymer micelles could be prepared using PNIPAAm-6-PLA block copolymers [149-152]. PMPC is also a well-known biocompatible polymer that suppresses protein adsorption and platelet adhesion, and has been used as the hydrophilic outer shell of polymer micelles consisting of a block copolymer of PMPC -co-PLA [153]. Many other vinyl-type polymers used for PLA-based amphiphilic block copolymers were also introduced in a recent review [16]. 

Fig. 1 Chemical structure of water-soluble poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate-co-p-vinylphenylboronic acid (PMBV)...

Tumoko and coworkers [485] showed that polymers based on acrylamide, methyl propane sulfonic acid and butyl methacrylate in conjunction with poly(2 methacryloyloxyethyl phosphorylcholine-co-butyl methacrylate) are capable of suppressing platelet adherence. Similar results [486] were found on poly(gamma benzyl 1 glutamate-co-leucine) neutralized with sodium. 

Kyomoto M, Moro T, Takatori Y, Kawaguchi H, Nakamura K, Ishihara K. Self-initiated surface grafting with poly(2-methacryloyloxyethyl phosphorylcholine) on poly(ether-ether-ketone). Biomaterials 2010 31(6) 1017-24. 

Kyomoto M, Moro T, Yamane S, Hashimoto M, Takatori Y, Ishihara K. Poly(ether-ether-ketone) orthopedic bearing surface modified by self-initiated surface grafting of poly(2-methacryloyloxyethyl phosphorylcholine). Biomaterials 2013 34(32) 7829- 39. 

Polymeric betaines or zwitterions are polyampholytes whose oppositely charged groups remote one from another are displaced on one pendant substituent. There are several types of monomers with a betaine structure carboxy-betaines, sulfobetaines and phosphobetaines. Poly-hT-ethyleneglycine (1), po-ly(N-3-sulfopropyl)-W-methacryloyloxyethyl-Nd -dimethylammonium betaine) (2) and poly[(2-methacryloyloxyethyl-2-(trimethylammonioethyl-phosphate)] (3) are typical examples of this kind of polyampholyte ... 

Next, in order to demonstrate the efficacy of this cell surface engineering approach, cell microarrays were prepared using a micropattemed poly(2-methacryloyloxyethyl phosphorylcholine [MPC]) (PMPC) polymer brush surface as the substrate. PMPC brushes were prepared on a silicon (Si) wafer via surface-initiated atom transfer radical polymerization, as previously described elsewhere [35]. Selective decomposition of the initiators immobilized on the Si wafer using UV light irradiation resulted in micropatterning of the... 

Asanuma Y, Inoue Y, Yusa S, Ishihara K. Hybridization of poly(2-methacryloyloxyethyl phosphorylcholine-block-2-ethylhexyl methacrylate) with segmented polyurethane for reducing thrombogenicity. Colloids Surf B Biointerfaces 2013 108 239-45. 

Feng, W., Zhu, S., Ishihara, K., Brash, J. L. (2005). Adsorption of fibrinogen and lysozyme on silicon grafted with poly(2-methacryloyloxyethyl phosphorylcholine) via surface-initiated atom transfer radical polymerization. Langmuir, 21, 5980-5987. 

Plasma treatments have also been applied to intraocular lenses (lOL) to prevent the formation of posterior capsular opacification, e.g. increasing their hydrophilicity and permitting cells to maintain their normal epithelial morphology,or reduce the risk for endophthalimitis, e.g. by coating with poly(2-methacryloyloxyethyl... 

Armes et al. [58] synthesized, via ATRP, biocompatible, thermoresponsive ABA triblock copolymers in which the onter A blocks are comprised of PNIPAm and the central B block is poly(2-methacryloyloxyethyl phosphorylcholine). This novel system is soluble in dilnte aqueous solution but forms free-standing physical gels at 37 °C due to hydro-phobic associations of the PNIPAm segments. The gelation process is reversible and shows potential applications in drug delivery and tissue engineering. 

Latterly, ladder-like polymers were synthesized by template polymerization of poly(2-methacryloyloxyethyl methacrylate) with different degrees of ladder. The process was carried out also by ATRP. ... 

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