Poly -L-glutamine

Weitere Untersuchungen befaBten sich mit den optischen Eigenschaften von Poly-l-benzyl-L-histidin und Poly-L-histidin (175) sowie der basenkatalysierten Bildvuig von cyclischen Verbindungen aus Poly-L-asparaginsaure- 8-benzylester und Poly-L-glutamin-y-benzylester (173). 

Early support for the role of polymer hydrophobicity came from a study (158) of the interaction of a series of nonionizable polypeptides (poly-DL-alanine and three derivatives of poly-L-glutamine) with SDS. Strongest interaction, as judged from the lowest T l value (from dye solubilization and electrical conductivity measurements) and highest ionic dissociation (a, from sodium ion activity measurements) of the complex, was obtained with the most hydrophobic member, viz., poly-DL-alanine, and vice versa. 

Zanamivir conjugated to poly-L-glutamine is much more active against influenza viruses in mice and ferrets than the drug itself. Pharmaceutical Research,... 

PHEG = poly-N5-(2-hydroxyethyl)L-glutamine PHPG = poly-N5-(3-hydroxypropyl)L-glutamine PHBG = poly-N5-(4-hydroxybutyl)L-glutamine PLA = poly-L-alanine... 

Water-soluble random copolymers containing L-serine and A/5-(4-hydroxybutyl)-L-glutamine are prepared, and the thermally induced helix-coil transition of these copolymers in water is studied. The Z/mm-Bragg parameters cr and s for the (hypothetical) helix-coil transition in poly(l-serine) in water are deduced. The values of s, computed from both the Lifson and Allegra theories are (.Llfson, o-1 x 10-4 / Allegra, o = 7.5 x 10 5 s - 0.667/0.726 (273 K), 0.757/0.784 (293 K), 0.777/0.792 (313 K), 0.731/0.744 (333 K),... 

The synthesis and characterization of water-soluble "random" copolymers containing t-valine with either A -O-hydroxypropyD-L-glutamine or / -(A-hydroxybutyD-L-glutamine are described, and the thermally induced helix-coil transitions of these copolymers in water are studied. The incorporation of /.-valine is found to decrease the helix content of the polymer at low temperatures and increase it at high temperatures. The Zimm-Bragg parameters o and s for the helix-coil transition in poly(t-valine) in water are deduced from an analysis of the melting curves of the copolymers. The values of s, computed for o = 1 x 1CI-4, are s 0.85 (273 K), 0.93 (293 K), 1.00 (313 K), 1.06 (333 Kl. 

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