Poly degradation, activator compound

Although Colby and Chamberlin62) failed to link the efficiency of polynucleotide interferon inducers to their sensitivity to pancreatic ribonuclease, it is unquestionable that the more effective interferon inducers [poly(I) - poly(C), poly(G) poly(C), thiophosphate-substituted poly(A-U) and poly(I-C), and thermally activated poly(A-U) and poly(I—C)] are all more resistant to nucleolytic degradation than the lesser active compounds [poly(A) poly(U), non-activated poly(A-U) and poly(I-C)] (Fig. 6 Refs.62 69> 70 72 7S)). However,... 

A new RNase activity, tentatively named RNase V, was found in cell-free extracts of E. coli. Ribonuclease V is an exoribonuclease attacking mRNA from 5 to 3 terminal producing 5 -mononucleotides. It is characterized by the requirements of ribosomes, G and T factors, tRNA, K+ or NH4+, Mg2+, GTP and a sulfhydryl compound by its specificity and by the fact that it degrades poly U, poly A, T4 phage mRNA or E. coli mRNA, but not ribosomal RNA (132). 

The reductive photodehalogenation of aryl halides has been actively investigated in recent years. Special attention has been given to (poly)halobenzenes and (poly)halo-biphenyls. The reactions are of interest in view of their mechanisms, and because of the importance of chlorinated aromatic hydrocarbons as environmental pollutants and the possibility of their photoinduced degradation. The photochemistry of aryl halides and related compounds in general14 and the photochemistry of polyhaloarenes in particular18 have been reviewed. 

Optically active polyaldehydes possessing optically active side chains, such as poly-(R)(+)-citronellal, poly-(R)(+)-6-methoxy-4-methylhexanal, and poly-(S)(+)-2-methylbutanal, have been prepared by Goodman (1, 22). The optical activity of the polymers was enhanced as compared with their model compounds. It was concluded that the enhancements of the optical activity arose from a conformational rigidity around the asymmetric center in the side chain of the polymer. From degradation studies of the polymers it was concluded that the optical activity of the monomer was unchanged, and no racemization had occurred during polymerization and degradation. 

A critical survey of the coordination chemistry of white phosphorus illustrating the metal-mediated degradation of the P4 tetrahedron is presented. The underlying principles to account for the activation and stepwise fragmentation of this molecule in the presence of transition metal complexes are presented with emphasis given to mechanistic aspects. A collection of 31P-NMR spectral data for the known poly phosphor us Px compounds (x < 4) is also presented and briefly commented. 

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