Poly 3-acrylamidophenylboronic

Film devices are often developed based on polymer backbone or framework. For example, a poly-pyrrole film with borane in the backbone has been obtained by direct electropolymerisation. Boronic acid derivatised pyrroles have been employed to make molecular imprinted polymers (MIPs), for example for the detection of dopamine. Figure 8.8 shows the concept of polymer formation in the presence of analyte followed by extraction to provide highly selective pockets for dopamine to bind. The read-out in this case is based on the Fe(CN)/" redox probe. Poly-amino-boronic acid films without imprinting were employed for dopamine detection. Co-polymer sensor films based on poly(aniline-co-3-aminobenzeneboronic acid) and poly(acrylamidophenylboronic acid) have been reported. 

Lapeyre et al. [99] prepared aqueous microgels consisting of thermorespon-sive PNIPAAm core and thermo- and glucose-responsive poly(NIPAAm-co-acrylamidophenylboronic acid) shell. The radius of the core in the collapsed state (40°C) was 65 nm. By variation of the monomer concentrations added during the second polymerization step from 20 to 80 mM, the shell thickness increased from 15 to 38 nm. 

Figure 14 Glucose responsive insulin release from poly(iV-isopro-pylacrylamide-co-acrylamidophenylboronic acid) copolymer gels. (From Ref. 88.)...

Wu et al. demonstrated that metal nanoparticles can be immobilized in stimuli-responsive microgels, and this system offers the possibilities of external switching and manipulation of sensor devices." The CdS hybrid microgels were synthesized through the in situ formation of CdS QDs in the interior of the copolymer microgel of poly(N-isopropylacrylamide-acrylamide-acrylamidophenylboronic acid) [p(NIPAM-AAm-PBA)]. It was... 

Similar to borax, boronic acid-containing polymers can also be used to crosslink polyhydroxy polymers, such as PVA. Kitano et al. reported the first example of an interpolymer complex based on boronate-diol interactions. The complex was formed by mixing a PVA solution and an alkali solution of poly(AI-vinyl-pyrrolidone-co-3-acrylamidophenylboronic acid). Complex formation leads to an increase in solution viscosity. Above a critical polymer concentration, the complex solution loses its fluidity to become a transparent gel. The authors later increased the solubility of the polymer under physiological and acidic aqueous conditions by incorporation a third comonomer, Af,Af-dimethylaminopropylacrylamide (DMAPAA). Therefore, an interpolymer complex can form at physiological pH. 

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