Polioviral Mediator of Host Cell Shut-off

All of these data indicate that a catalytic activity is present in poliovirus-infected cells which can inactivate the function of the cap recognition complex. Each of these observations represents a potential assay for the purification of the inactivator, but this has not yet 

Virus-specific phosphorylation of ribosomal proteins and/or proteins associated with ribosome preparations has been described (Ter-shak, 1978 James and Tershak, 1981) and thought to be a possible regulatory reaction involved in inhibition of cellular protein synthesis. Although no data are available to relate the phosphorylation events with the regulation of protein synthesis, it is interesting that one of 

At the present time, it is assumed that a viral gene product either acts directly or indirectly to cause inactivation of the cap recognition system in HeLa cells. However, direct identification of the mediator of the inactivation has not been demonstrated. 

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