Poisons overdose

Sometimes people take a dare to consume large amounts of alcohol and die from alcohol poisoning (overdose). 

Emetics are used to cause vomiting to empty the stomach rapidly when an individual has accidentally or intentionally ingested a poison or drug overdose Not all poison ingestions or drug overdoses are treated with emetics. 

Death from overdose of barbiturates may occur and is more likely when more than 10 times the hypnotic dose is ingested. The barbiturates with high lipid solubility and short half-lives are the most toxic. Thus the lethal dose of phenobarbital is 6—10 g, whereas that of secobarbital, pentobarbital, or amo-barbital is 2-3 g. Symptoms of barbiturate poisoning include CNS depression, coma, depressed reflex activity, a positive Babinski reflex, contracted pupils (with hypoxia there may be paralytic dilation), altered respiration, hypothermia, depressed cardiac function, hypotension, shock, pulmonary complications, and renal failure. 

Haddad EM, Winchester JE, eds. 1990. Clinical management of poisoning and drug overdose. 2nd ed. Philadelphia, PA WB Saunders Company, 1083-1087. 

Haddad LM, Shannon MW, Winchester JF, eds. 1998. Clinical Management of Poisoning and Drug Overdose. 3rd edition. Philadelphia (W.B. Saunders). 413-425. 

Muscarine, an alkaloid from certain species of mushrooms, is a muscarinic receptor agonist. The compound has toxicologic importance muscarine poisoning will produce all of the effects that are associated with an overdose of ACh (e.g., bronchocon strict ion, bradycardia, hypotension, excessive salivary and respiratory secretion, and sweating). Poisoning by muscarine is treated with atropine. 

Olson, Kent R., ed. Poisoning Drug Overdose. 4th ed. New York Lange Medical Books/McGraw-Hill, 2004. 

Deaths from overdoses of other types of hallucinogens are rare, but not with PCP. Poisoning with this drug is a major medical emergency and requires great skill in management. Fortunately, the means are available for successful treatment. 

Donovan, J.W. 1990. Nitrates, nitrites and other sources of methemo-globinemia. In L.M.Haddad and J.F.Winchester, eds., Poisoning and Drag Overdose, 2nd... 

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