Poisonings traditional African

Garcinia kola Heckel (seeds) 3",4, 4", 5,5",7,7"-Heptahydroxy-3,8-biflavanone (GBi) (176) GB2 (177) Kolaviron (KV) [a mixture of (C-3,C-8)-linked biflavonoids GBi (177) + GB2 (177) + kolaflavanone (178)]. Traditional medicine in the West and Central African sub-region. Poison antidote. Seeds have been used in traditional African medicine to treat diabetes. Antioxidant and antihepatotoxic properties. KV showed antioxidant, hepatoprotective and hypoglycaemic effects. KV inhibited rat lens aldose reductase (RLAR) activity, had antidiabetic and hypolipidaemic effects, and showed immunomodulatory and immunorestorative properties. Maurice, 1982[186] Iwu et al., 1987[187], 1990[101] Farombi et al., 2000[188] Adefule-Ositelu et al., 2004[189] Adaramo ye and Adeyemi, 2006[190, 191] Nworu et al., 2008[192] Okoko, 2009[113]. 

V Stenkamp, M. J. Stewart, and M. Zuckerman, Clinical and analytical aspeas of pyrrolizidine poisoning caused by South African traditional medicines , Therapeutic Drug Monitoring, 22 (2000), 302. 

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