Point protein folding studies

It is worthwhile at this point to briefiy discuss several problems from the field of protein folding, as they bear a strong similarity to those of computational drug design and have been studied for a longer time. Three fundamental problems underlying most research on protein folding are ... 

The strongest advantage of the FTIR approach as a structure-specific probe is that a complete spectrum is available for each time point of measurement. Methods to study protein folding by stopped-flow FTIR have been reviewed.In this way, several spectral windows are accessible simultaneously for the observation of the formation of different secondary structure elements and also events that can be attributed to changes in tertiary structure. One specific advantage of the infrared technique is the ability to monitor directly the kinetics of processes involving jS-sheet structures, which is exceptionally difficult to do with other techniques. 

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