Podophyllinic acid lactone

Podophyllotoxin 1-0-glucoside (= Podophyllinic acid lactone 1-0-glucoside) (lignan)... 

Synonyms 5,8,8A,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3 ,4 6,7]naphtho[2.3-d]-l,3-dioxol-6(5aH)-one podophyllinic acid lactone podofilox... 

In addition to effects on biochemical reactions, the inhibitors may influence the permeability of the various cellular membranes and through physical and chemical effects may alter the structure of other subcellular structures such as proteins, nucleic acid, and spindle fibers. Unfortunately, few definite examples can be listed. The action of colchicine and podophyllin in interfering with cell division is well known. The effect of various lactones (coumarin, parasorbic acid, and protoanemonin) on mitotic activity was discussed above. Disturbances to cytoplasmic and vacuolar structure, and the morphology of mitochondria imposed by protoanemonin, were also mentioned. Interference with protein configuration and loss of biological activity was attributed to incorporation of azetidine-2-carboxylic acid into mung bean protein in place of proline. 

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