Pluronic polymeric micelles studies

Polymeric micelles to deliver photosensitizeis for photodynamic therapy van Nostmm CF Pluronics poly(ethylene glycol)-lipid conjugates pH-sensitive PiPAAm-based micelles polyion complex micelles dmg loading biodistribution studies therapeutic efficiency 2004 [65]... 

Among the most commonly used thermosensitive polymers are poly(iV-isopropylacrylamide) (pNIPAAm) and pluronics (polyethylene glycol-b-polypropylene oxide-b-polyethylene glycol, PEG-h-PPO-h-PEG). The most extensively studied thermosensitive polymer is pNIPAAm with an LCST of 32°C. This has been used as a hydrophobic block of polymeric micelles with a PEG corona, as well as a hydrophilic shell combined with several other hydrophobic blocks. Work on the synthesis and applications of NIPAAm polymers as components for DDS (in most cases micelles) has been extensively described in several reviews over the years (Aoshima and Kanaoka, 2008 Schmaljohann, 2006 TaleUi and Hennink, 2011 Wei c/ /.,2009). 

Another study also utilized the technique of encapsulation of the chemotherapeutic agent within polymeric micelles in combination with a local ultrasonic irradiation of the tumor. Pure and mixed Pluronic P-105, PEG2000-diacylphospholipid, and... 

In a detailed study of the adsorbed DHBCs chain conformation, Hamley et al. have presented experimental results on adsorbed Pluronic triblock copolymers onto both silica and mica substrates [106]. The experimental data were obtained for a wide range of bulk polymer concentrations, even below the critical micelle concentration. The results indicate that, depending on the hydrophilicity of the substrate, the copolymer chains are adsorbed in a completely different way. Moreover, it was concluded that the polymer concentration plays a significant role on the conformation of the adsorbed polymeric layer. 

PEO-PPO, and later on PEO-PBO copolymers, represent the link between classical low molecular weight non-ionic surfactants and polymeric surfactants. These commercially available products (formerly known as POLOXAMERS, PLURICARE, PLURONICS, SYN-PERONICS), mainly with di- and triblock structures can form, depending on temperature and concentration, true solutions, micelles of different shapes and physical gels. Their micellization behavior has been studied quite extensively and the experimental as well as the theoretical results were summarized in the review articles of Nace [10], Chu and Zhou [116], Ahngren etal. [147], Hamley [11], Booth and co-workers [79,148] and Wanka etal. [149]. 

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