Platinum peptide complexes

The interaction of platinum(II) complexes with various amino acids and simple peptides is relevant to understanding the biological fate of platinum anticancer agents such as mplatin, and this area has been reviewed extensively.258-261... 

The peptide bond that is cleaved is the bond between Leu-189 and Asp-190. There are two peptide bonds in close proximity to the iron chelate on Cys-212. The other peptide bond is between He-144 and Gly-145. The Cys-212 sulfur is 5.1 A from the carbonyl carbon of Gly-145, and 5.3 A from the carbonyl carbon of Leu-189. However, the main difference is that the peptide bond of Leu-189-Asp-190 is oriented parallel to Cys-212, while the peptide bond of lie-144-Gly-145 is oriented away for Cys-212. As was seen with cobalt(lll) hydrolysis of peptide bonds, the proximity and orientation of the carbonyl carbon is important for hydrolysis. This approach has been extended to the cleavage of multisubunit proteins. Palladium(n) and platinum(ll) complexes as synthetic peptidases have been reviewed elsewhere. ... 

Peptide-tethered platinum(ll) complexes have been prepared using solid-supported techniques and gel-phase Pt-195 NMR spectroscopy used as a non-destructive analytical method for on-support analysis. This... 

In collaboration with the Dai group, Lippard and Feazell employed noncovalently PEGylated SWNTs to attach by peptide linkage and deliver a platinum(IV) complex to... 

Guillena G, Rodriguez G, Albrecht M, van Koten G (2(X)2) Covalently bonded platinum(ll) complexes of a-amino acids and peptides as a potential tool for protein labeling. Chem Eur J 8 5368-5376. doi 10.1002/15213765... 

Peptide hydrolysis by platinum(II) (436) and palladium(II) complexes (437). In the latter case there is selective hydrolysis of the unactivated peptide bond in iV-acetylated L-histidylglycine the hydrolysis rate depends on the steric bulk of the catalyst. 

Acetyl ligands, in niobium complexes, C-H BDEs, 1, 298 Achiral phosphines, on polymer-supported peptides, 12, 698 Acid halides, indium compound reactions, 9, 683 Acidity, one-electron oxidized metal hydrides, 1, 294 Acid leaching, in organometallic stability studies, 12, 612 Acid-platinum rf-monoalkynes, interactions, 8, 641 Acrylate, polymerization with aluminum catalysts, 3, 280 Acrylic monomers, lanthanide-catalyzed polymerization,... 

NMR data were used to prove the structure of peptide-coupling reagents -[(6-nitrobenzotriazol-lyl)oxy]tris(dimethylamino)-, -(pyrrolidino)phosphonium hexafluorophosphates [829-831], l-(2-nitrobenzenesulfonyloxy)-6-nitrobenzotri-azole [832], and l-(2-naphthylsulfonyloxy)-6-nitrobenzotriazole [833], complexes of 5-nitrobenzotriazole with palladium(II) and platinum(II) [834], some explosive substances such as 1-picrylbenzotriazole mono- and polynitro derivatives [835] as well as that of the Mesenheimer a-complexes and 4,6-dinitrobenzotriazole-l-oxide [836, 847],... 

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