Platinum group metals anticancer drugs

In our group, a major part of our research is devoted to the design of new anticancer drugs. Our recent efforts towards the discovery of new platinum-, ruthenium- and osmium-based anticancer agents provide the topic for this account and a section is devoted to each metal. We focus on recent results from our lab in the context of other developments and related research in this field (hence our coverage of the field is focused on these areas and is not comprehensive). 

Inorganic biochemists are also interested in two other classes of metals those that occur as environmental or other pollutants (lead, cadmium, mercury, aluminum in Alzheimer s disease etc.), and those which are important in medicine (lithium in mental health, platinum in anticancer drugs, gold in rheumatoid arthritis). The last group is considered in Chapter 62.2. 

A coordination compound is a compound in which a central metal ion (or atom) is attached to a group of surrounding molecules or ions by coordinate covalent bonds. A good example is the anticancer drug dsplatin, Pt(NH3)2Cl2, in which two NH3 molecules and two Cl ions use lone pairs of electrons to bond to the platinum(II) ion ... 

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