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Platinum -containing cytotoxic drugs

The development of the platinum (Pt) -containing cytotoxic drugs for the treatment of solid tumors is a major success story of analogue-based drug discovery. Very soon after the introduction of the first Pt complex into clinical practice, three main goals for the development of subsequent derivatives were formulated ... [Pg.385]

The structure of the adducts of platinum derivatives with DNA continues to be of interest because of their use and potential as anticancer drugs. The specificity of DNA interstrand cross-links formed between the ineffective rranj-diamminechloroplatinum(II) has been determined as being preferentially between complementary guanine and cytosine residues. In addition, the rate of cross-linking with the trans isomer was found to be lower than that for the clinically active cis compound. The NMR solution structure of a DNA duplex containing the cis-platinumdiammine N7(G), N7(G) adduct has been determined. A second NMR structure examines adduct formation in an intrastrand cross-link created in a self-complementary duplex. A pair of enantiomeric Pt(II) complexes has been synthesised and their cytotoxicity has been evaluated. [Pt(RR-eaP)Cl2] (eap= N,N-diethyl-2,4-pentadiamine) was found to be more active in leukaemia cells but the difference was not as great as expected. ... [Pg.253]

See other pages where Platinum -containing cytotoxic drugs is mentioned: [Pg.2667]    [Pg.2849]    [Pg.943]    [Pg.2667]    [Pg.2849]    [Pg.943]    [Pg.287]    [Pg.290]    [Pg.420]    [Pg.479]    [Pg.3606]    [Pg.7]    [Pg.611]    [Pg.211]    [Pg.211]    [Pg.222]    [Pg.291]    [Pg.120]    [Pg.491]    [Pg.234]    [Pg.28]    [Pg.22]    [Pg.6]    [Pg.23]    [Pg.28]    [Pg.187]    [Pg.246]    [Pg.958]    [Pg.448]   
See also in sourсe #XX -- [ Pg.385 ]



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Platinum-containing

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