Platinate, dichloro

The experimental determination of the rate constants for the platination of different oligonucleotides has turned out to be rather difficult. To avoid the complicacy due to the CL hydrolysis of the dichloro species,... 

Dichloro(l,5-cyclooctadiene)platinum(II) may be prepared from hexachloro-platinic acid,3 by heating bis(benzonitrile)dichloroplatinum(II)4 in 1,5-cyclo-... 

N2Cl202PtC6Hi4, Platinum(ll), cw-dichlorobis-(propanoneoxime)-, 34 82 N2Cl202PtC6Hi4, Platinum(ll), trani-dichloro-bis(propanoneoxime)-, 34 83 N2Cl30PtCi9H43, Platinate(ll), trichloro(propa-noneoxime)-, tetra(n-butyl)ammonium, 34 82... 

Tetrammino-platinous salts are known containing pyridine in place of ammonia. Thus, diammino-dipyridino-platinous salts have been prepared. These salts are interesting, as they exist in isomeric forms, and through them the configuration of the isomeric diacido-diammino-platinous compounds have been determined. It is well known that diacido-diammino-platinum exists in stereo-isomeric forms. These isomers react with two molecules of pyridine in such a manner that pyridine replaces acidic radicles in the complex with formation of diammino-dipyTidino-platinous salts. Depending upon which isomer is treated with pyridine, two different diammino-dipyridino-platinous salts are produced. Cis- or unsymmetrical dichloro-diammino-platinum is... 

Propylenediamino-diammino-platinous Chloride, [Pt(NH3)2 pn]Cl2, is produced by the cautious addition of ammonia to dichloro-propylenediamino-platinum, [PtpnClJ, suspended in boiling water. 

Hydroxylamine plays the same part in the molecule as ammonia in ammino-platinum compounds, but the substances differ somewhat in chemical behaviour, for hydroxylamine is more readily eliminated than ammonia from the complex. Also, m-dihydroxylamino-dichloro-platinum is not obtained by the interaction of free hydroxylamine and potassium chloroplatinite, the method used for the preparation of cis-dichloro-diammino-platinum. Again, tetrammino-platinous hydroxide, [Pt(NH3)4](OH)2, is a very strong base and easily soluble in water, whilst tetrahydroxylamino-platinous hydroxide, [Pt(NH2OH)4](OH)2, is almost insoluble in water and a comparatively weak base.2 For this reason Werner 3 suggested a different formula for the two substances, and indicated that possibly in the tetrahydroxylamino-com-pound the co-ordination number of the metal is six and not four, as in the tetrammino-compounds thus ... 

Complex platinous derivatives containing hydrazine are easily prepared by acting upon dichloro-diammino-platinum with hydrazine hydrate in absence of water. The addition of alcohol precipitates diammino-dihydrazino-platinous chloride in colourless prismatic... 

Chloro-triammino-platinous Chloride, [Pt(NH3)3Cl]Cl, may be obtained by the addition of ammonia to dichloro-diammino-platinum, [Pt(NH3)2Cl2], or by the elimination of ammonia from tetrammino-platinous chloride by the action of hydrochloric acid thus ... 

Gis-dichloro-diammino-platinum, [Pt(NH3)2Cl2], was first prepared by Peyronne.2 It is easily formed by adding ammonia to a cold solution of platinous chloride in hydrochloric acid, when a greenish-yellow voluminous precipitate separates. This is boiled with water and filtered hot, when, on cooling the filtrate, the substance crystallises in yellow microscopic needles. It is sparingly soluble in water, and is more pure yellow than the isomeric trans-compound. Both cis- and fraws-dichloro-diammino-platinum are obtained on heating tetrammino-platinous chloride with hydrochloric acid. 

Hydrocliloric acid slowly transforms it into potassium chloropiatinite, and ammonia into dichloro-diammino-platinuni, chloro-triammino-platinous chloride, and tetrammino-platinous chloride. Chlorine oxidises it, forming the corresponding salt of the platinic series. 

In the annnino-platinous compounds there is, as in the other amniino-metallic compounds, a complete transition series from tetrammino-platinous salt to tetra-acido-platinous salt for example, tetrammino-platinous chloride, [Pt(NH3)JC12, chloro-triammino-platinous chloride, [Pt(NH3)3Cl]Cl, dichloro-diammino-platinum, [Pt(NH3)2Cl2], trichloro-ammino-platinous salt, [Pt(NH3)Cl3]K, and potassium chloropiatinite, [PtCl6]K2, where all the ammonia is replaced by chlorine. Comparing the molecular conductivities, the first-mentioned compound has conductivity at 1000 litres dilution of 260, the next 115-8 in the third compound the conductivity drops almost to zero, the fourth has conductivity of 106-8, and the last salt has conductivity of 267.2... 

Dichloro-tetrammino-platinic Chloride, [Pt(NH8)4Cl2]Cl2, is prepared by passing chlorine gas through a solution of tetrammino-platinous chloride till the liquid begins to turn red. From the cold dilute solution the salt crystallises with one molecule of water of crystallisation, whilst from more concentrated solutions the anhydrous salt is deposited. It may also be obtained by the action of ammonia on tetraehloro-dianunino-platinum. It crystallises in pale yellow microscopic oetahedra, is sparingly soluble in water, and only half of the chlorine is precipitated as silver chloride when the aqueous solution is treated with a cold solution of silver nitrate. Sulphuric acid eliminates only two molecules of chlorine.1... 

Dichloro - tetrammino - platinic Bromide, [Pt(NH3)4Cl2]Br2, is produced by treating the nitrate of the series with ammonium bromide, when the salt is precipitated as a yellow crystalline powder. Silver nitrate replaces two atoms of bromine by two nitrate radicles. 

Dichloro - tetrammino - platinic Sulphate, [Pt(NH3)4Cl2JS04, separates as a white crystalline powder when sulphuric acid is added to a warm aqueous solution of the nitrate. If the solution be kept cool a hydrated salt separates in small needles. The salt is sparingly soluble in water, and silver nitrate does not remove chlorine from a cold aqueous solution. 

Dichloro-tetrammino-platinic Nitrate, [Pt(NH3)4Cl2](N03)2, is obtained by treating tetrammino-platinous chloroplatinite with small quantities of nitric acid. It crystallises in slightly yellow prisms. 

The chloroplatinite, [Pt (NH 3) 4C12]PtCl 4, may be prepared by the action of chloroplatinic acid on tetrainmino-platinous chloride, or by the action of chlorine on Magnus green salt suspended in boiling water. It is a red crystalline substance which is only7 slightly7 soluble in water. Silver nitrate transforms the salt into a mixture of silver chloroplatinite and dichloro-tetrammino-platinic nitrate. 

The chloroplatinate, [Pt(NH3)4Cl2]PtCl6, is obtained by mixing solutions of sodium chloroplatinate and dichloro-tetrammino-platinic nitrate, or by the prolonged action of chlorine on either the green salt of Magnus or the preceding salt suspended in -water. It crystallises in brilliant yellow prisms which are soluble in hot water. Hydrochloric and nitric acids precipitate the chloride and the nitrate respectively.2... 

Dibromo-tetrammino-platinic Chloride, [Pt(NH3)4Br2]Cl2, is isomeric with dichloro-tetrammino-platinic bromide. It is formed by double decomposition between ammonium chloride and dibromo-tetrammino-platinic nitrate, when the salt separates as a yellow crystalline powder. Silver nitrate precipitates all the chloride and one atom of bromine in the molecule. 

Dinitrato - tetrammino - platinic Chloride, [Pt(NH3)4(N03)2] C12.H20, is prepared by treating a boiling solution of hydroxo-nitrato-tetrammino-platinic nitrate, [Pt(NH3)4(0H)(N03)](N03)2, with hydrochloric acid. It separates as a white crystalline powder which may be reerystallised from water in large rhombic crystals. It is soluble in cold water, and loses water of hydration on heating to 100° C. Chlorine is completely precipitated by silver nitrate it therefore differs in this respect from the nitrate of dichloro-tetrammino-platinic series, with which it is isomeric. 

It is conveniently prepared by treating dichloro-tetrammino-platinic nitrate with silver nitrate. It crystallises in small white... 

A solution of 20.8 g. (55 mmoles) of potassium tetrachloro-platinate(II) in 100 ml. of water is prepared in a 250-ml. suction flask with a nitrogen flow through the sidearm to provide an inert atmosphere. (The procedures work equally well at halfscale.) Triethylphosphine (15 ml., 100 mmoles) is added all at once and the mixture is stirred with a magnetic stirrer at room temperature for one hour. A pink-tan precipitate of tetrakis-(triethylphosphine)platinum(II)tetrachloroplatinate(II) forms. The mixture is heated on a steam bath for one hour. The pink salt dissolves, and a layer of pale yellow dichloro-bis(triethyl-phosphine)platinum forms on the liquid. The solid is filtered, washed with water, crushed in a mortar, and dried under... 

Platination Step, i) Starting from the dichloro complex, the first aquation (1) (Scheme 2) is rate-determining, but the kinetic data do not tell which is/are the actual DNA-platinating species in the various conditions, ii) The kpi rate constants differ by one order of magnitude from 0.3 to 2.5 m-1 s-1 [48] [78] [82], but the value of 2.08 0.07 m-1 s-1 that we have also deter-... 

SYNS CACP CDDP CISPLATINO (SPANISH) CISPLATYL CPDC CPDD DDP ds-DDP cis-DIAMMINEDICHLOROPLATINUM cis-DICHLORO-DIAMMINE PLATINUM(II) NCI-C55776 NEOPLA-TIN NSC-119875 PEYRONE S CHLORIDE PLATIBLASTIN cis-PLATIN PLATINEX ... 

Katalysatoren wie ds-Dichloro-bis-[triphenylphosphan]-platin(II) und Rhodium-Kom-plexe sind weniger geeignet. 

Such polymerization can be avoided by using a catalyst composed of a Group VIII metal or a derivative thereof, e.g., platinum (as platinum black or platinized asbestos or charcoal), hydrogen hexachloroplatinate, or ruthenium chloride then the 1 1 adducts can be obtained in good yield from olefins such as styrene, acrylonitrile, and methacrylic esters with, e.g., dichloro(methyl)-silane 347-349 nevertheless it is advantageous to exclude oxygen and add a polymerization inhibitor such as te/7-butylpyrocatechol or 2,6-di-terf-butyl-4-methylphenol. 

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