Platelet dense granules

McNicol A, Israels SJ. 1999. Platelet dense granules Structure, function and implications for haemostasis. Thromb Res 95 ... 

Identiflcation of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome. /oo(/77 101-112,1991. 

Israels SJ, Gerrard jm, Jacques YV, McNicol A, Cham b, Nishibori M, Bainton DF. Platelet dense granule membranes conhan both granulophysin and P-sdeclin(GMP-140). /oo(/80 143-152,1992. 

Feng, L, Novak, EK, Hartnell, LM, Bonifacino, JS, Collinson, LM, and Swank, RT, The Hermansky-Pudlak syndrome 1 (hpsl) and hps2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysos-omes. Blood, 2002. 99(5) 1651-1658. 

Chromaffin granules, platelet dense core vesicles, and synaptic vesicles accumulate ATP. ATP uptake has been demonstrated using chromaffin granules and synaptic vesicles and the process appears to depend on A(.lh+. It has generally been assumed that ATP is costored only with monoamines and acetylcholine, as an anion to balance to cationic charge of those transmitters. However, the extent of ATP storage and release by different neuronal populations remains unknown, and the proteins responsible for ATP uptake by secretory vesicles have not been identified. 

Platelets adherent to collagen change shape and spread out on the subendothelium. They release the contents of their storage granules (the dense granules and the alpha granules) secretion is also stimulated by thrombin. 

Dense granule storage pool deficiency Deficiency of dense granules in megakaryocytes and platelets... 

Lages B, Holmsen H, Weiss HJ, Dangelmaier C. 1983. Thrombin and ionophore A23187-induced dense granule secretion in storage pool deficient platelets Evidence for impaired nucleotide storage as the primary dense granule defect Blood 61 154-162. 

Reddington M, Novak EK, Hurley E, Medda C, McGarry MP, et al. 1987. Immature dense granules in platelets from mice with platelet storage pool disease. Blood 69 1300-1306. 

Serotonin binds to the platelet 5-HTj receptor coupled to PLC via a G protein. The human serotonin receptor has been cloned and have the usual seven transmembrane domain form (Saltzman et al., 1991). Serotonin is rapidly taken up by passive diffusion and by a high affinity eneigy-dependent carrier, and is released upon platelet activation by secretion ftom the dense granules (Pletscher, 1987). 

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