Platelet cohesiveness

High intakes of the long-chain CO-3 polyunsaturated fatty acids (as found in fish oils) may additionally provide protection against thrombosis, as they form the 3-series eicosanoids, which inhibit platelet cohesiveness. 

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Fibronectin is present in plasma, subendothelium and platelet alpha granules. Despite containing the RGD sequence, the role of fibronectin in adhesive and cohesive properties of platelets seems less important. It has been suggested that plasma fibronectin would not be required for platelets to adhere on vascular extracellular matrices [45]. However, studies with plasma depleted of fibronectin seem to indicate that this adhesive protein could play a role in mediating adhesion of platelet and thrombus formation on collagen rich surfaces [46]. As will be commented on later, the mote recent studies suggest that vascular fibronectin would mediate platelet adhesion under certain experimental conditions [47]. 

The platelets subsequently release adenosine diphosphate (ADP) which results in the cohesion of additional platelets thus forming the nucleus around which fibrin is formed (by activation of the intrinsic coagulation system). Entrapment of red and white blood cells follows and a full-blown throndOus results. 

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