Platelet aggregation ginkgo

Kudolo GB, Dorsey S, Blodgett J. Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. Thromb Res 2003 108 151-160. 

I Ginkgo biloba—reported to decrease platelet aggregation and blood viscosity through imknown mechanism. Effective in controlled studies. Side-effects include subarachnoid or subdural haemorrhage. 

No. Ginkgo products interfere with platelet aggregation and thus make the actions of anticoagulant drugs less predictable. 

Gardner, C.D., J.L. Zehnder, A.J. Rigby, J.R. Nicholus, and J.W. Farquhar. 2007. Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease A randomized clinical trial. Blood Coagul. Fibrinolysis 18(8) 787-793. 

A series of diterpenes from Sideritis (Lamiaceae) species have anti-inflammatory activity. These plants also contain anti-inflammatory flavonoids (Alcaraz and Rios, 1991). Gingkolides from Ginkgo biloba have anti-inflammatory activity and antagonize platelet aggregation factor (Walton, 1992). 

Dutta-Roy AK. Inhibitory effect of ginkgo biloba extract on human platelet aggregation. Platelets 1999 10 298-305. 

Ginkgolide B is a selective antagonist of platelet aggregation induced by platelet-activating factor (PAF). PAF, an inflammatory autacoid, is involved in various inflammatory, cardiovascular, and respiratory disorders. " Ginkgo extract has also displayed anti-inflam-matroy activity in a number of conditions and disease models such as colitis, arthritis, skin inflammation, and rat paw edema. " Antiinflammatory mediators have been suppressed by the extract. ... 

Koch E (2005) Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 12(1-2) 10-16... 

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