Platelet-aggregating factor, antagonists

Phospholipids, 19 (1982) 111 Photodecomposition of drugs, 27 (1990) 51 Plasmodium, 43 (2005) 190 Plasmodium flaciparum dihydrofolate reductase (PfDHFR), 43 (2005) 226 Platelet-aggregating factor, antagonists, 27 (1990) 325... 

PCT0061587, 2001FRP2791980, 2003USP6433167) were thesis of tetracyclic antagonists of platelet aggregation factor typical approaches is presented in the Scheme... 

The oxazolidinone-based compounds are the most common (Figure 23.1), and examples include antibacterial,27-28 adhesion receptor antagonists,29-30 tumor necrosis factor inhibitors,31 platelet aggregation inhibitors,32 antimigraine drugs,33 and monoamine oxidase inhibitors.3435 In one case, an oxazolidinone has been used as a transdermal drug delivery agent.36... 

On the basis of these results it has been suggested that electronic factors— Hammett s sigma (a) constant, dipole moment (/z) and Swain and Lupton s polarity (F)—are crucial for the antithrombotic activity of these compounds. Interestingly, in all the active compounds presented in Fig. 24 the arrangement of substituents around the thiazole skeleton is different from one another. This has further widened the scope of this skeleton in the exploration of potential platelet aggregation inhibitors and thromboxane A2 receptor antagonist. 

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