Platelet adhesion and aggregation

Degrades ADP (an aggregating agent of platelets) to AMP -t P Inhibits platelet adhesion and aggregation by elevating levels of cGMP... 

Bennett JS Mechanisms of platelet adhesion and aggregation an update. Hosp Pract (Off Ed) 1992 27 124. 

Glycoprotein llb/llla Platelets allbps ICAM-2 Fibrinogen, fibronectin, von Willebrand factor Platelet adhesion and aggregation... 

Endotoxin activates complement, which then augments the inflammatory response through stimulation of leukocyte chemotaxis, phagocytosis and lysosomal enzyme release, increased platelet adhesion and aggregation, and production of toxic superoxide radicals. 

NSAIDs by decreasing platelet adhesion and aggregation, can prolong bleeding time by about 3 to 4 minutes. 

Abnormal activation of platelets is associated with increased platelet adhesion and aggregation and therefore a higher incidence of thrombotic events. Platelet activation also leads to release of smooth muscle mitogens such as growth factors and thromboxane. Nitric oxide is a potent inhibitor of platelet adhesion and aggregation. Thus, endothelial dysfunction and the associated decrease in nitric oxide generation may result in abnormal platelet function. Platelets also contain both... 

Ramasamy I. Inherited bleeding disorders disorders of platelet adhesion and aggregation. Crit rev Oncol Hematol 2004 49 1-35. 

Platelet Adhesion and Aggregation under Dynamic Shear... 

Muggli R, Baumgartner HR, Tsdiopp TB, Keller H Automated microdensitometry and protein assays as a measure for platelet adhesion and aggregation on collagen-coated slides under controlled flow conditions. J Ld> Clin Med 95 195-207, 1980. 

Coccheri, S. and Florentinin, P. Platelet adhesiveness and aggregation in hypertensive patients. Acta... 

There have been various reports that metformin increases fibrinolysis, reduces thrombus formation (Weichert and Breddin, 1988) and reduces platelet adhesiveness and aggregation (Holmes et al., 1984). This, however, was mostly felt to be secondary to improved glycaemic control, because similar effects have been reported with sulphonylureas (Vague et al., 1987). In healthy subjects, biguanides should therefore not be used to increase fibrinolytic activity. 

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