Poisoning plasmapheresis

Therapeutic plasma exchange (TPE), or plasmapheresis (PP), is an extracorporeal therapy most frequently used in the treatment of hematologic disorders, and autoimmune neuropathies and vasculitides [37]. This modality occasionally is also employed in the treatment of poisoning. The apparatus involves central venous access and a blood circuit between the patient and a pheresis machine. Cytopheresis by centrifugation or filtration then separates the formed elements of blood from plasma. The cells are returned to the patient while the plasma (with the poison) is discarded. Fluid volume is typically replaced with crystalloid, colloid, or fresh frozen plasma (FFP) if clotting factor repletion is necessary. [Pg.256]

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