Plasma Lipid Transfer Proteins

Plasma lipid transfer proteins, which include the cholesteryl-ester-transfer-protein (CETP previously known as lipid transfer protein I, LTP-I) and the phospholipid-transfer-protein (PLTP previously known as lipid transfer protein II, LTP-II) mediate the transfer of lipids (cholesteryl esters, triglycerides and phospholipids) between lipoproteins present in human plasma. These proteins significantly affect plasma lipoprotein concentration and composition. 

Tall A (1995) Plasma lipid transfer proteins. Annu Rev Biochem 64 235-257... 

Jiang XC, Zhou HW (2006) Plasma lipid transfer proteins. Curr Opin Lipidol 17 302—308... 

Many larger lipid carrier proteins are known. The 476-residue plasma cholesteryl ester transfer protein is discussed briefly in Chapter 22. Plasma phospholipid transfer proteins are of similar size.t/U A 456-residue human phospholipid-binding protein interacts with the lipopolysaccharide of the surfaces of gram-negative bacteria (Fig. 8-30) and participates in the immune response to the bacteria. It has an elongated boomerang shape with two cavities, both of which bind a molecule of phosphatidylcholine. Other plasma lipid transfer proteins may have similar structures/... 

Plasma Lipid Transfer Proteins and Enzymes Concerned with Lipid... 

A17. Albers, J. J., Tollefson, J. H., Chen, C.-H., and Steinmetz, A., Isolation and characterization of human plasma lipid transfer proteins. Arteriosclerosis 4, 49-58 (1984). 

A33. Abbey, M., Bastiras, S., and Calvert, G. D., Immunoprecipitation of lipid transfer protein activity by an antibody against human plasma lipid transfer protein-I. Biochim. Biophys. Acta 833, 25-33 (1985). 

H9. Harmony, J. A. K., Jackson, R. L., Ihm, J., Ellsworth, J. L., and Demel, R. A., Interaction of a human plasma lipid transfer protein complex with lipid monolayers. Biochim. Biophys. Acta 690, 215-223 (1982). 

In hepatocytes, vitamin E can take two routes. A fraction of it is packaged as VLDL and reenters the circulation, while excess is excreted in the bile. Plasma lipolysis of the VLDL particle again results in release not only of lipids, but also of vitamin E, with the remainder left with the LDL particles. This fraction can be further distributed to tissues via LDL receptor-mediated endocytosis or transferred between lipoproteins, mainly to HDL, by plasma lipid transfer proteins. Thus, mobilization of vitamin E from intestinal and liver... 

Tall, A. H. (1986). Plasma lipid transfer proteins, f. Lipid Res. 27,361-367. 

Tall, A. (1995) Plasma Lipid Transfer Proteins, Ann. Rev. Biochem. 64,235-251. 

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