Plasma-induced activation

Slang, E., L. E. Johannessen, S. L. Knardal, and 1. H. Madshus. Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation. J Biol Chem. 275 13940-7.2000. 

This pentasaccharide sequence induces a conformational change in AT III which probably causes the complex to be more accessible to the active site of the proteases. The most relevant protease affected by the pentasaccharide 3 is factor Xa, but factor Xlla and plasma kallikrein activities can also be potentiated. Sequence 3 occurs in heparin as well as in various heparan sulfate proteoglycans of different origin including the vascular endothelium. 

The newer anticonvulsants have not been studied as intensively as the older drugs, but felbamate, oxcarbaze-pine, and topiramate have enzyme-inducing activity and reduce plasma steroid concentrations (331). 

In animal studies, Cassano and D mello found that stress-induced activation of the HPA axis stimulated the release of both facilitatory and inhibitory components [109]. Stress can alter plasma corticosterone-binding globulin levels, and aminoglutethimide administration can cause accumulation of the corticosterone biosynthetic precursor, adrenal cholesterol. Their results indicated that stress-induced facilitation of the HPA axis is associated with the release of serotonin [109]. Djordjevic et al. also investigated the reaction of the HPA system to various stressors (fasting, crowding, cold, and heat) by... 

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