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Plasma average, drug accumulation from

Calculation of drug accumulation from the "average" plasma concentration... [Pg.234]

In a study by Burns et al 9 in which the plasma levels of meperidine hydrochloride were measured after intravenous injection in man, it was inferred that metabolism occurs at a rate varying from 10 to 20 per hour (17 average) in ten different subjects. No accumulation of the drug after repeated administration was found in this study and only 5 of the drug was found to be excreted unchanged in the urine. Plotnikoff et al3l determined that the biotransformation products of meperidine hydrochloride excreted in human urine are normeperidine (I), meperidinic acid (II), nor-... [Pg.192]

See other pages where Plasma average, drug accumulation from is mentioned: [Pg.260]    [Pg.34]    [Pg.48]    [Pg.41]    [Pg.33]    [Pg.2070]    [Pg.113]    [Pg.74]   
See also in sourсe #XX -- [ Pg.234 ]



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Drug accumulation

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