Plaque formation suppression

Plaque formation suppressant. Water extract of the rhizome was inactive on Streps tococcus mutans. The methanol and metha-nol/water extracts were active ICjo were greater than 1000, 60, and 230 pg/mL, respectively . ... 

Plaque formation suppressant Sanguinarine Isoquinoline alkaloid 1069... 

Endothelin-1 (ET-1) is a small polypeptide with vasoconstrictive and mitogenic properties. ET-1 originates from endothelial cells and VSMCs, and induces the replacement of endothelial cells by neointimal SMC during arthro-sclerotic plaque formation. Induction of ET-1 expression in SMCs by HjOj-evoked oxidative stress is inhibited by resveratrol." Moreover, resveratrol pretreatment suppresses ET-1-mediated protein tyrosine phosphorylation and MAPK activation, leading to SMCs proliferation and contraction. ... 

In other studies, we also showed that resveratrol effectively suppressed proliferation of cultured bovine pulmonary aortic endothelial cells (BPAEC). These results imply that resveratrol, delivered to endothelial cells in sufficient concentrations to inhibit proliferation in vivo, could facilitate rapid and efficient repair of damages on the endothelium, with the overall effect of decreasing the probability of sustained endothelial injury and exposure of the subendothelial matrix, which would trigger the formation of atherosclerotic plaques and the development of... 

Elevated lipoprotein concentration contributes to the formation of atherosclerotic plaques and in some cases pancreatitis. Occlusion of blood vessels by atherosclerotic plaques causes tissue infarction (e.g., stroke, myocardial infarction), which is frequently fatal. Pharmacologic reduction of serum lipoprotein levels suppresses the development of atherosclerosis. 

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