Plakortis lita

Ethyl plakortide Z (19) and its two didehydro analogs (20a and 20b) are found in the Papuan sponge Plakortis lita. These compounds are cytotoxic and show some antitumor activity in vitro. ... 

Haterumadioxins A and B were isolated from the Okinawan sponge Plakortis lita. Haterumadioxin A 100 was evaluated against a human cancer cell line panel and found to be effective against a melanoma cancer cell line. An analysis of the results obtained... 

In the marine environment, several polyketides with important medicinal value have been reported in recent years. They have been isolated mainly from marine sponges of the genus Caltyspongia and Plakortis, which yielded potent cytotoxic polyketides, e g., callystatin A, Fig. (52) isolated from Callyspongia trunccitci [285,431], and several cyclic polyketides named plakortides, Fig. (53), isolated from Plakortis lita [432] and Plakortis simplex [433],... 

R. A. Davis, S. Duffy, S. Fletcher, V. M. Avery, R. J. Quinn, J. Org. Chem. 2013, 78, 9608-9613. Thiaplakortones A-D antimalarial thiazine alkaloids from the Australian marine sponge Plakortis lita. 

De Guzman, F.S. and Schmitz, F.J. (1990) Peroxy aliphatic esters from the sponge Plakortis lita. J. Nat. Prod., 53,926-931. 

Sakemi, S., Higa, T., Anthoni, U., and Christophersen, C. (1987) Antitumor cydic peroxides from the sponge Plakortis lita. Tetrahedron, 43, 263—268. 

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