Pizotifen, migraine prophylaxis

Crowder D, Maclay WP. Pizotifen once daily in the prophylaxis of migraine results of a multi-centre general practice study. Curr Med Res Opin 1984 9(4) 280-5. 

Pizotifen 500 micrograms three times daily for 8 days in 14 healthy subjects was found to have no significant effect on the pharmacokinetics of sumatriptan. In addition, there were no significant changes in blood pressure or heart rate. In a clinieal study, the addition of pizotifen prophylaxis did not alter the efficacy of acute sumatriptan for migraine relief. In this study, the eombination was assoeiated with more weight gain than sumatriptan alone, an effeet whieh was attributed solely to the pizotifen. ... 

Cleland PG, Barnes D, Elrir tcn GM, Loizou LA, Rawes GD Studies to assess if pizotifen prophylaxis improves migraine beyond the benefit offered by acute sumatriptan theraiiy alone. Eur Neurol ( 997) 38, 31-8... 

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