4-Piperidino-6-chloropyrimidine

The.effect of the entropy of activation was noted above for the quaternary pyridine salts (280 and 281). In future work, it may also be found to reflect the electrostatic or hydrogen-bonding interactions in transition states of amination reactions and the effect of reversible cationization of an azine-nitrogen. Brower et observed a substantial rate difference between piperidino-dechlorinations of 2-chloropyrimidine in petroleum ether and in alcohol due partly to the higher entropy of activation in the latter solvent (Table III, lines 3 and 4). 

The influence of the nature of the substituent at position 4. In order to determine the influence of substituents at position 4 on the Sn(ANRORC) process in the aminodehalogenation, the amide-induced amination was studied with 6-chloropyrimidines containing different substituents at position 4, i.e., the 4-Ubutyl-, 4-methoxy-, 4-piperidino-, 4-anilino-, and 4-methyl-groups (79RTC5). The results are summarized in Table ILl. 

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