Piperidine, molecular model structure

Picric acid, synthesis of, 628 Pinacol rearrangement, 646 Pineapple, esters in, 808 Piperidine, molecular model of, 939 structure of. 918 P1TC, see Phenylisothiocyanate, 1031-1032... 

Fig. 8.7 Two-dimensional (a) and space-flUing three-dimensional baU-and-stick (b, left hand side) and CPK (b, right hand side) molecular models of morphine showing in color the identified allergenic determinant recognized by the IgE antibodies in the papaveretum-eilleigic patient (refer Figs. 8.5 and 8.6). The individual fine-structural features of the determinant are shown in different colors the piperidine ring (ring D) attached to the cyclo-...

Katritzky et al. (2008PNAS7359) successfully developed classification ANN QSAR for 200 compounds used as repellents against mosquitoes. Mosquito repellent activities from USDA archives of N-acylpiperidines were extracted and modeled using molecular descriptors calculated by CODESSA PRO software. The ANN model was used for the correlation of these archival repellent activities and used to predict the activities of novel compounds of similar structures. The outcome of this QSAR led to a selection of 34 promising mosquito N-acylpiperidine repellent candidates which were synthesized by reactions of acylbenzotriazoles with piperidines. These synthesized compounds were screened as topical mosquito repellents by... 

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