Thrombocytopenia piperacillin + tazobactam

Reichardt P, Handrick W, Linke A, Schille R, BQess W. Leukocytopenia, thrombocytopenia and fever related to piperacillin/tazobactam treatment—a retrospective analysis in 38 children with cystic fibrosis. Infection 1999 27(6) 355-6. 

Perez-Vazquez A, Pastor JM, Riancho JA. Immune thrombocytopenia caused by piperacillin/tazobactam. Clin Infect Dis I998 27(3) 650-I. 

Piperacillin/tazobactam has been associated with thrombocytopenia. A 74-year-old woman on continuous renal replacement therapy developed severe thrombocytopenia (19,000/mm ) a week after the initiation of piperacillin/ tazobactam. After discontinuation of piperacillin/fazobacfam, the platelet coxmt recovered within 3 days. Piperacillin/tazobactam should be considered as a causative agent for thrombocytopenia in this type of patient [39 ]. 

Thrombocytopenia with penicillins has very rarely been reported (57-61). In two cases with mezlocillin (62) and piperacillin + azobactam (63) antibodies became attached to the platelets in the presence of the incriminated drug. The second of these cases is of particular interest, since drug-dependent antibodies were found in the presence of piperacillin but not tazobactam. 

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