Piperacillin interaction with methotrexate

Clinically important, potentially hazardous interactions with amoxicillin, ampicillin, antacids, bacampicillin, calcium carbonate, carbenicillin, cloxacillin, digoxin, methotrexate, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, ticarcillin, zinc... 

Clinically important, potentially hazardous interactions with acitretin, aluminum hydroxide, amoxicillin, ampicillin, antacids, bacampicillin, betamethasone, bismuth, bromelain, calcium, carbenicillin, cholestyramine, doxacillin, corticosteroids, dairy products, dicloxacillin, didanosine, digoxin, food, glidazide, iron, isotretinoin, methicillin, methotrexate, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, retinoids, rocuronium, strontium ranelate, sucralfate, ticarcillin, vitamin A, zinc... 

The more basic interactions between piperacillin and methotrexate and its major metabolite 7-hydroxymetho-trexate have been stndied in rabbits (255). The interaction was mainly cansed by rednced renal clearance of both methotrexate and its metabolite. The anthors concluded that renal function in patients taking this combination should be monitored, with adequate fluid intake, especially in elderly patients, because dehydration may accelerate the occurrence of toxicity. 

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See also in sourсe #XX -- [ ]

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