Piperacillin adverse effects

Thrombocytopenia is a rare adverse effect of vancomycin and may be associated with the presence of vancomycin-dependent antiplatelet IgG antibodies. Reports of drug-induced thrombocytopenia have been systematically reviewed (51). Among the 98 different drugs described in 561 articles the following antibiotics were found with level I (definite) evidence co-trimoxazole, rifampicin, vancomycin, sulfisoxazole, cefalothin, piperacillin, methicillin, novobiocin. Drugs with level II (probable) evidence were oxytetracycline and ampicillin. 

Psychiatric Adverse psychiatric effects have been attributed to piperacillin [105" ]. 

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