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Pioglitazone hydrochloride

USAN Pioglitazone hydrochloride Trade name Actos ... [Pg.117]

A number of syntheses of pioglitazone have been disclosed (Arita and Mizuno, 1992 Fischer et al., 2005 Les et al., 2004 Meguro and Fujita, 1986, 1987 Momose et al., 1991 Prous and Castaner, 1990 Saito et al., 1998). Two related syntheses (Fischer et al., 2005 Les et al., 2004) of pioglitazone hydrochloride are described in Scheme 8.2. The tosylate of 2-(5-ethylpyridin-2-yl)ethanol (16), formed in situ with tosyl chloride, was displaced by 4-hydroxybenzaldehyde (17) by means of benzyltributylammonium chloride and NaOH to give 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde (20). Condensation of 20 with thiazolidine-2,4-dione in basic medium afforded 5-[-4-[2-(5-ethylpyridin-2-yl)ethoxy]benzylidene]thiazolidine-2,4-dione (21). Finally, this compound was hydrogenated to provide pioglitazone (2). Alternatively, a nucleophilic aromatic substitution reaction... [Pg.123]

Blake EW. Pioglitazone hydrochloride/glimepiride. Drugs Today (Bare) 2007 43(7) 487-97. [Pg.777]

Pioglitazone hydrochloride, a thiazolidinedione, acts primarily by decreasing insulin resistance. It improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. It also improves glycemic control while reducing circulating insulin levels. [Pg.280]

Aronoff S, Rosenblatt S, Braithwaite S, Egan JW, Mathisen AL, Schneider RLThe Pioglitazone 001 Study Group. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes a 6-month randomized placebo-controlled dose-response study. Diabetes Care 2000 23(11) 1605-11. [Pg.470]

Kipnes MS, Krosnick A, Rendell MS, Egan JW, Mathisen AL, Schneider RL. Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus a randomized, placebo-controlled study. Am J Med 2001 lll(l) 10-7. [Pg.470]

Actos Pioglitazone hydrochloride U-72107A. Antidia-betic agent. Insulin sensitizer. Crystals mp = 193-194. Takeda Chem. Ind. Ltd. [Pg.501]

Actos pioglitazone hydrochloride). Takeda Pharmaceutical Ccmpany Ltd US Prescribir information, February 2007. [Pg.380]

Actos (Pioglitazone hydrochloride). Takeda UK Ltd. UK Summary of product characteristics, January 2007. [Pg.497]

Pectin and sodium alginate Pioglitazone hydrochloride Menthol Matrix film (Hiroji Megba et al., 2012)... [Pg.461]

Radhakrishna, T. Rao, S. Reddy, G.O. Determination of pioglitazone hydrochloride in bulk and pharmaceuticals by HPLC and MEKC methods. J. Pharm. Biomed. Anal. 2002, 29 (4), 593-607. [Pg.105]

See other pages where Pioglitazone hydrochloride is mentioned: [Pg.147]    [Pg.507]    [Pg.325]    [Pg.332]    [Pg.995]    [Pg.460]    [Pg.2753]    [Pg.2753]    [Pg.2753]    [Pg.2754]    [Pg.180]    [Pg.501]    [Pg.752]    [Pg.1056]    [Pg.462]    [Pg.149]   
See also in sourсe #XX -- [ Pg.117 , Pg.122 , Pg.124 ]

See also in sourсe #XX -- [ Pg.995 ]



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Actos - Pioglitazone hydrochloride

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