Pindolol pharmacokinetics

Goldberg MJ, Bergstrom RF, Cerimele BJ, Thomassom HR, Hatcher BL, Simcox EA. Fluoxetine effects on pindolol pharmacokinetics. Clin Pharmacol Ther 991)6, 178. 

Ghosh, T.K. Adir, J. Xiang, S.-L. On3ulofur, S. IVansdermal delivery of metoprolol II In-vitro skin permeation and hioavailability in hairless rats. J.Pharm.Sci., 1995, 84, 158—160 [rat plasma pindolol (IS) fluorescence detection LOD 5 ng/mL pharmacokinetics]... 

Silipo C and Vittoria A, Relationships between octanol-water partition data, chromatographic indices and their dependence on pH in a set of beta-adrenoceptor blocking agents, Farmaco, 45, 647-663 (1990). See also Hinderling PH, Schmidlin O and Seydel JK, Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in man, J. Pharmacokin. Biopharm., 12, 263-287 (1984). Taylor EA, Jefferson D, Carroll JD and Turner P, Cerebrospinal fluid concentrations of propranolol, pindolol, and atenolol in man Evidence for central actions of beta-adrenoceptor antagonists, Br. J. Clin. Pharmacol, 12, 549-559 (1981). NB See Pindolol for furdter details. 

A double-blind, crossover study in 8 healthy subjects found that over a 5-day period, metoprolol 100 mg twice daily did not affect the pharmacokinetics of felodipine 10 mg twice daily. On the other hand, the bioavailability and peak plasma levels of metoprolol were increased by 31% and 38%, respectively. Another study in 10 healthy subjects given felodipine 10 mg with either metoprolol 100 mg, pindolol 5 mg, propranolol 80 mg, or timolol 10 mg found no changes in heart rate, PR interval or blood pressure that might be considered to be harmful to patients with hypertension or angina. However, 7 of the 10 subjects reported some inerease in adverse effects. ... 

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