Pilot Scale Data and Scaleup

It is necessary to ensure that the feed stream characteristics are representative of all essential characteristics, such as age of feed sample, temperature, concentration of all components (suspended and soluble), and pH. The filtration time needed to perform a desired final concentration of retained solids or percent recovery of product passing across the membrane filter (the permeate) must also be consistent with the actual process requirements. 

Effects of sample age, duration of exposure to shear and heat, may be very important and must be considered. In the demonstration scale phase, the operating configuration (e.g., batch, feed and bleed, continuous) specified for the production scale system must be used. Carefiil consideration must be given to the total pressure drop in the flow chaimels at the desired cross-flow velocity at the final concentration, to ensure proper design of the feed and recirculation pumps. 

Organic citrate, tartrate gluconate Acldlc/alkallne solutions 

Proteins Enzymes, yeast. Mild to moderately alkaline 

Biological debris E-Coll. bacteria cell walls Moderately alkaline 

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