Phytoconstituents with Hypocholesterolemic Potentials

SOME HYPOCHOLESTEROLEMIC, ANTI ATHEROSCLEROTIC AND ANTI THROMBOTIC NATURAL PRODUCTS 

Indole-3-carbinol Brassica species Hypocholesterolemic Peluso and Schneeman (1994) 

P-Sitosterol and sitostanol Many plants Hypocholesterolemic Gylling and Miettinen (1996) 

Saponin Fenugreek, Bupleurum chinense, Gyrostemma pentaphyllum, etc. Hypocholesterolemic Miettinen et al. (1995) 

Dietary fiber Beans, Hordeum vulgare, juglans nigra, etc. Hypocholesterolemic Story et al. (1984) 

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Compounds with different structures but with the same therapeutic activity isolated from different plant species act as active moieties for the treatment of particular diseases. Some of these compounds have been abandoned due to toxicity but these compounds apparently do not cause serious adverse effects. Some of these active principles originate from edible plants and their inclusion in the diet would undoubtedly be of some value because of their hypocholesterolemic potential. Several phytoconstituents including inulin, pectin, gugglu lipids, flavonoids, ginkoloids, saponins, tannins, and others obtained from various plant sources have proven hypolipidemic potentials as has been further explained in Tables I and II. The chemical structures of a few potential phytoconstituents with hypolipidemic activity are shown in Figure 2. It is hoped that as new additions are made to the list of these active compounds causing only minimum untoward side effects, these naturally... 

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