Physostigmine interaction

Fig. 12.3 Schematic representation of the interactions of acetylcholine esterase (AChE) with acetylcholine (ACh) (upper part) and with physostigmine (lower part). Left AChE com-plexed with the substrate. Middle acylated AChE (inactive). Deacylation by hydrolysis or otherwise leads to the regenerated active enzyme (Right).

Carbamylated enzymes that carry a much longer (C=0)-N-substituent, have a considerably longer off-rate. The N-heptyl analogue of physostigmine (see below) has a tVi of 11 days, but this was attributed to a hydrophobic interaction between the chain and the enzyme. 

Harris, L.W., Lennox, W.J. and B.G. Talbot. 1984. Toxicity of anticholinesterase Interactions of pyrdiostigmine and physostigmine with soman. Drug Chem. Toxicol. 7 507—526. (cited in Somani et al., 1992)... 

In overdose, physostigmine can reverse life- pressants interact are summarized in Table 3 those of... 

Clinically important, potentially hazardous interactions with galantamine, physostigmine... 

Clinically important, potentially hazardous interactions with bethanechol, cimetidine, donepezil, edrophonium, physostigmine, pilocarpine, rivastigmine, succinylcholine, tacrine... 

Clinically important, potentially hazardous interactions with amikacin, aminoglycosides, galantamine, gentamicin, kanamycin, neomycin, paromomycin, physostigmine, pipecuronium, streptomycin, tobramycin, vancomycin, vecuronium... 

Mewaldt, S. P., Ghoneim, M. M. (1979). The effects and interactions of scopolamine, physostigmine and methamphetamine on human memory. Pharmacology Biochemistry and Behavior, 10, 205-210. 

Harris L, Lennox W, Talbot BG et al. (1984). Toxicity of anticholinesterases interaction of pyridostigmine and physostigmine with soman. Drug Chem Toxicol, 7, 507-526. 

Dube, S.N., Somani, S.M., and Colliver, J.A., Interactive effects of physostigmine and exercise on cholinesterase activity in RBC tissues of rat, Part-I. Arch. Int. Pharmacodyn. 

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