Physiologically-based pharmacokinetic future models

FUN tool is a new integrated software based on a multimedia model, physiologically based pharmacokinetic (PBPK) models and associated databases. The tool is a dynamic integrated model and is capable of assessing the human exposure to chemical substances via multiple exposure pathways and the potential health risks (Fig. 9) [70]. 2-FUN tool has been developed in the framework of the European project called 2-FUN (Full-chain and UNcertainty Approaches for Assessing Health Risks in FUture ENvironmental Scenarios www.2-fun.org). 

Overall, the illustrated example of modeling metabolic lability shows that global in silico ADMET models are successful tools to optimize ADMET parameter. Future predictions of ADMET models might be added into complex tools such as physiological-based pharmacokinetic models yielding an in silico engine for ADMET support [98]. 

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