Physiological modulators hypoxia

Nakayama, K., et al., Siah2 regulates stability of prolyl-hydroxylases, controls HlFla abundance and modulates physiological responses to hypoxia. Cell, 2004, 117(7), 941-52. 

Ky currents in vascular smooth muscle cells have diverse properties. The existence of multiple Ky currents within a given artery, or of the differential distribution between different vascular beds, is unknown. More understanding of the properties and distribution of individual Ky channels may shed some light on their physiological role, and remains an important goal for future research. Inhibition of Ky channels may be involved in hypoxia and vasoconstrictor-induced membrane depolarization. The predicted modulation of Ky channels by vasodilators and vasoconstrictors will also be an important area of future investigation. 

Neubauer, J.A., Melton, J.E., and Edelman, N.H. 1990. Modulation of respiration during breiin hypoxia. Journal of Applied Physiology 68 441-451 Nilsson, G.E. and Lutz, P.L. 1991. Release of inhibitory neurotransmitters in response to anoxia in turtle brain. The American Journal of Physiology (AJP) — Legacy 26LR32-R37 Owen, O.E., Morgan, A.P., Kemp, H.G., Sulhvan, J.M., Herrera, M.G., and Cahill, G.Rjr. 1967. 

In conclusion, EPO expression is induced by hypoxia via activation of HIF-1. The P02-dependent modulation of ROS levels within the physiological range of PO2 values can modulate EPO gene expression. HIF-1 regulation, however, depends on oxygen-sensitive hydroxylation of prohne residues of HIF-la by prolyl hydroxylases... 

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