Physicochemical and Pharmaceutical Aspects

Plasma Protein Fractions I. Physicochemical and Pharmaceutical Aspects 

Among the colloids prepared from human blood and used for plasma volume expansion, human serum albumin (HSA) and plasma protein fractions (PPF) are the most important products. HSA is a monodisperse, relatively symmetrical protein with a calculated molecular weight between 66,300 and 69,000 daltons, prepared from plasma by fractionation (for review, see Tullis 1977). PPF is a solution of plasma proteins containing about 85% albumin and 15% globulins of which the 

The first case of an anaphylactoid reaction to the intravenous diagnostic administration of Tc -labeled human albumin microspheres was recently reported (Littenberg 1975). The symptoms comprised flush, severe bronchospasm, and rapid fall of blood pressure to unmeasurable levels. The patient recovered following treatment with epinephrine, benadryl, and hydrocortisone. 

---

Liquid-liquid and solid-liquid dispersed systems are complicated forms from a physicochemical point of view, because of the presence of two phases. Their formulation therefore necessitates comprehension of fundamental aspects controlling the behavior of these systems. With this end in view, we begin this volume with theoretical considerations concerning pharmaceutical surfactants, formulation concepts, and emulsion properties, and the related know-how to attain them. As the text progresses, each chapter becomes more advanced and specific. Thermodynamic and kinetic aspects of suspension formulations, as well as... 

---