Physical property tests differential scanning calorimetry

Differential scanning calorimetry can be used to detect isosorbide dinitrate in the presence of various proportions of other isohexide mononitrates in pharmaceutical formulations81 and for testing its hazardous characteristics.82 A complete analytical profile for isosorbide dinitrate, detailing spectroscopic and other physical properties, as well as useful analytical methods, has been reported.83... 

Physical properties were determined by differential scanning calorimetry (dsc) with a Perkin-Elmer DSC-4 instrument and by dynamic mechanical thermal analysis (dmta) using a Polymer Laboratories dmta instrument. Stress-strain tests were performed on an Instron Table Model TM-M at a cross-head speed of 1mm min. The Young s modulus was obtained from the tangent of the initial slope of the force vs. elongation curve. Scanning electron microscopy (s.e.m.) employed an AMR 900 instrument. Specific experimental details are given elsewhere (9,10,11). 

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