Phyllanthus niruri hypophyllanthin from

Hussain et al. [202] isolated three lignans from Phyllanthus niruri which were identified as phyllanthin, hypophyllanthin and nirtetralin. They were also found to inhibit [125I]-ET-1 binding to the recombinant human ETA receptor expressed in Chinese hamster ovary cells (CHO-ETa), but were inactive against the recombinant ETb receptor. Hypophyllanthin was the most potent compound, with an IC50 value of 40 pM. 

---